If you need tags to be destroyed / removed, PLEASE have a developer do it -- otherwise you will edit-push hundreds of questions to the front page for no good reason, and add revision history that is meaningless.
So, carry on, just be sure to ping us for en-masse changes like this so we can do them without disruption to the site.
edit: per request, I have blacklisted the tag ^vmware$ now that it no longer exists. Well done everyone!