What about this question? It's discussing worm infections on a LAN rather than viruses but it's all malware at the end of the day. I've tried to edit my answer to the question to make a bit more broad in scope.
How do I deal with the removal/eradication of an unknown worm on our network?
If you're talking about individual machines in an individual context, as you mention small business, then SU may have some stuff that's more orientated towards that scale of things. A lot of our assumptions on SF about 'nuke from orbit' implicitly include the idea that the business will have some tools and procedures to make rebuiling a system 'low cost' compared to the time and effort taken to clean an infected machine and that might not be true for a small business.